Sometimes. If you pay for your shipping charges, your order will ship via USPS (and USPS delivers to PO Boxes). However, if your order is over $75 and you select FREE SHIPPING, your order will likely ship via UPS, and UPS does not deliver to PO Boxes. Therefore, if you select Free Shipping as your shipping method, you must provide us with a valid address that is not a PO Box. We do apologize for this inconvenience.